Helminth-Tuberculosis Co-infection: An Immunologic Perspective

Chronic Helminth Infection Does Not Exacerbate Mycobacterium tuberculosis Infection

BACKGROUND Chronic helminth infections induce a Th2 immune shift and establish an immunoregulatory milieu. As both of these responses can suppress Th1 immunity, which is necessary for control of Mycobacterium tuberculosis (MTB) infection, we hypothesized that chronic helminth infections may exacerbate the course of MTB. METHODOLOGY/PRINCIPAL FINDINGS Co-infection studies were conducted in cot...

Tuberculosis/hiv Co-infection

Tuberculosis (TB) and human immunodeficiency virus/acquired immune deficiency syndrome (HIV/ AIDS) constitute the main burden of infectious disease in resource-limited countries. Estimates by the World Health Orgnisation (WHO) indicate that there are more than nine million new active cases of TB and close to two million deaths per year and 2.6 million new cases of HIV infection and 1.8 million ...

Intestinal helminth co-infection and associated factors among tuberculosis patients in Arba Minch, Ethiopia

BACKGROUND Helminths affect the outcome of tuberculosis by shifting cell mediated immune response to humoral and by total suppression of the host immune system. On the reverse, Mycobacterium infection favors immune escape of helminths. Therefore assessing helminth co-infection rate and predisposing factors in tuberculosis patients is mandatory to set strategies for better case management. MET...

Co-endemicity of Pulmonary Tuberculosis and Intestinal Helminth Infection in the People’s Republic of China

Both pulmonary tuberculosis (PTB) and intestinal helminth infection (IHI) affect millions of individuals every year in China. However, the national-scale estimation of prevalence predictors and prevalence maps for these diseases, as well as co-endemic relative risk (RR) maps of both diseases' prevalence are not well developed. There are co-endemic, high prevalence areas of both diseases, whose ...

Co-infection with HIV and Mycobacterium tuberculosis: immunologic interactions, disease progression, and survival.